| Round | Pick | Team | Player | Position | College |
| 1 | 1 | Cincinnati Bengals | Joe Burrow | QB | Louisiana State |
| 1 | 2 | Washington Football Team | Chase Young | DE | Ohio State |
| 1 | 3 | Detroit Lions | Jeff Okudah | DB | Ohio State |
| 1 | 4 | New York Giants | Andrew Thomas | T | Georgia |
| 1 | 5 | Miami Dolphins | Tua Tagovailoa | QB | Alabama |
| 1 | 6 | Los Angeles Chargers | Justin Herbert | QB | Oregon |
| 1 | 7 | Carolina Panthers | Derrick Brown | DT | Auburn |
| 1 | 8 | Arizona Cardinals | Isaiah Simmons | LB | Clemson |
| 1 | 9 | Jacksonville Jaguars | CJ Henderson | DB | Florida |
| 1 | 10 | Cleveland Browns | Jedrick Wills | T | Alabama |
| 1 | 11 | New York Jets | Mekhi Becton | T | Louisville |
| 1 | 12 | Las Vegas Raiders | Henry Ruggs | WR | Alabama |
| 1 | 13 | Tampa Bay Buccaneers | Tristan Wirfs | T | Iowa |
| 1 | 14 | San Francisco 49ers | Javon Kinlaw | DT | South Carolina |
| 1 | 15 | Denver Broncos | Jerry Jeudy | WR | Alabama |
| 1 | 16 | Atlanta Falcons | A.J. Terrell | DB | Clemson |
| 1 | 17 | Dallas Cowboys | CeeDee Lamb | WR | Oklahoma |
| 1 | 18 | Miami Dolphins | Austin Jackson | T | USC |
| 1 | 19 | Las Vegas Raiders | Damon Arnette | DB | Ohio State |
| 1 | 20 | Jacksonville Jaguars | K'Lavon Chaisson | DE | Louisiana State |
| 1 | 21 | Philadelphia Eagles | Jalen Reagor | WR | Texas Christian |
| 1 | 22 | Minnesota Vikings | Justin Jefferson | WR | Louisiana State |
| 1 | 23 | Los Angeles Chargers | Kenneth Murray | LB | Oklahoma |
| 1 | 24 | New Orleans Saints | Cesar Ruiz | C | Michigan |
| 1 | 25 | San Francisco 49ers | Brandon Aiyuk | WR | Arizona State |
| 1 | 26 | Green Bay Packers | Jordan Love | QB | Utah State |
| 1 | 27 | Seattle Seahawks | Jordyn Brooks | LB | Texas Tech |
| 1 | 28 | Baltimore Ravens | Patrick Queen | LB | Louisiana State |
| 1 | 29 | Tennessee Titans | Isaiah Wilson | T | Georgia |
| 1 | 30 | Miami Dolphins | Noah Igbinoghene | DB | Auburn |
| 1 | 31 | Minnesota Vikings | Jeff Gladney | DB | Texas Christian |
| 1 | 32 | Kansas City Chiefs | Clyde Edwards-Helaire | RB | Louisiana State |
| Round | Pick | Team | Player | Position | College |
| 2 | 33 | Cincinnati Bengals | Tee Higgins | WR | Clemson |
| 2 | 34 | Indianapolis Colts | Michael Pittman | WR | USC |
| 2 | 35 | Detroit Lions | D'Andre Swift | RB | Georgia |
| 2 | 36 | New York Giants | Xavier McKinney | DB | Alabama |
| 2 | 37 | New England Patriots | Kyle Dugger | DB | Lenoir-Rhyne |
| 2 | 38 | Carolina Panthers | Yetur Gross-Matos | DE | Penn State |
| 2 | 39 | Miami Dolphins | Robert Hunt | G | Louisiana-Lafayette |
| 2 | 40 | Houston Texans | Ross Blacklock | DT | Texas Christian |
| 2 | 41 | Indianapolis Colts | Jonathan Taylor | RB | Wisconsin |
| 2 | 42 | Jacksonville Jaguars | Laviska Shenault | WR | Colorado |
| 2 | 43 | Chicago Bears | Cole Kmet | TE | Notre Dame |
| 2 | 44 | Cleveland Browns | Grant Delpit | DB | Louisiana State |
| 2 | 45 | Tampa Bay Buccaneers | Antoine Winfield | DB | Minnesota |
| 2 | 46 | Denver Broncos | KJ Hamler | WR | Penn State |
| 2 | 47 | Atlanta Falcons | Marlon Davidson | DE | Auburn |
| 2 | 48 | Seattle Seahawks | Darrell Taylor | DE | Tennessee |
| 2 | 49 | Pittsburge Steelers | Chase Claypool | WR | Notre Dame |
| 2 | 50 | Chicago Bears | Jaylon Johnson | DB | Utah |
| 2 | 51 | Dallas Cowboys | Trevon Diggs | DB | Alabama |
| 2 | 52 | Los Angeles Rams | Cam Akers | RB | Florida State |
| 2 | 53 | Philadelphia Eagles | Jalen Hurts | QB | Oklahoma |
| 2 | 54 | Buffalo Bills | AJ Epenesa | DE | Iowa |
| 2 | 55 | Baltimore Ravens | J.K. Dobbins | RB | Ohio State |
| 2 | 56 | Miami Dolphins | Raekwon Davis | DT | Alabama |
| 2 | 57 | Los Angeles Rams | Van Jefferson | WR | Florida |
| 2 | 58 | Minnesota Vikings | Ezra Cleveland | T | Boise State |
| 2 | 59 | New York Jets | Denzel Mims | WR | Baylor |
| 2 | 60 | New England Patriots | Josh Uche | LB | Michigan |
| 2 | 61 | Tennessee Titans | Kristian Fulton | DB | Louisiana State |
| 2 | 62 | Green Bay Packers | AJ Dillon | RB | Boston College |
| 2 | 63 | Kansas City Chiefs | Willie Gay | LB | Mississippi State |
| 2 | 64 | Carolina Panthers | Jeremy Chinn | DB | Southern Illinois |
| Round | Pick | Team | Player | Position | College |
| 3 | 65 | Cincinnati Bengals | Logan Wilson | LB | Wyoming |
| 3 | 66 | Washington Football Team | Antonio Gibson | WR | Memphis |
| 3 | 67 | Detroit Lions | Julian Okwara | DE | Notre Dame |
| 3 | 68 | New York Jets | Ashtyn Davis | DB | California |
| 3 | 69 | Seattle Seahawks | Damien Lewis | G | Louisiana State |
| 3 | 70 | Miami Dolphins | Brandon Jones | DB | Texas |
| 3 | 71 | Baltimore Ravens | Justin Madubuike | DT | Texas A&M |
| 3 | 72 | Arizona Cardinals | Josh Jones | T | Houston |
| 3 | 73 | Jacksonville Jaguars | DaVon Hamilton | DT | Ohio State |
| 3 | 74 | New Orleans Saints | Zack Baun | LB | Wisconsin |
| 3 | 75 | Detroit Lions | Jonah Jackson | G | Ohio State |
| 3 | 76 | Tampa Bay Buccaneers | Ke'Shawn Vaughn | RB | Vanderbilt |
| 3 | 77 | Denver Broncos | Michael Ojemudia | DB | Iowa |
| 3 | 78 | Atlanta Falcons | Matt Hennessy | C | Temple |
| 3 | 79 | New York Jets | Jabari Zuniga | DE | Florida |
| 3 | 80 | Las Vegas Raiders | Lynn Bowden | WR | Kentucky |
| 3 | 81 | Las Vegas Raiders | Bryan Edwards | WR | South Carolina |
| 3 | 82 | Dallas Cowboys | Neville Gallimore | DT | Oklahoma |
| 3 | 83 | Denver Broncos | Lloyd Cushenberry | C | Louisiana State |
| 3 | 84 | Los Angeles Rams | Terrell Lewis | DE | Alabama |
| 3 | 85 | Indianapolis Colts | Julian Blackmon | DB | Utah |
| 3 | 86 | Buffalo Bills | Zack Moss | RB | Utah |
| 3 | 87 | New England Patriots | Anfernee Jennings | DE | Alabama |
| 3 | 88 | Cleveland Browns | Jordan Elliott | DT | Missouri |
| 3 | 89 | Minnesota Vikings | Cameron Dantzler | DB | Mississippi State |
| 3 | 90 | Houston Texans | Jonathan Greenard | DE | Florida |
| 3 | 91 | New England Patriots | Devin Asiasi | TE | UCLA |
| 3 | 92 | Baltimore Ravens | Devin Duvernay | WR | Texas |
| 3 | 93 | Tennessee Titans | Darrynton Evans | RB | Appalachian State |
| 3 | 94 | Green Bay Packers | Josiah Deguara | TE | Cincinnati |
| 3 | 95 | Denver Broncos | McTelvin Agim | DT | Arkansas |
| 3 | 96 | Kansas City Chiefs | Lucas Niang | T | Texas Christian |
| 3 | 97 | Cleveland Browns | Jacob Phillips | LB | Louisiana State |
| 3 | 98 | Baltimore Ravens | Malik Harrison | LB | Ohio State |
| 3 | 99 | New York Giants | Matt Peart | T | Connecticut |
| 3 | 100 | Las Vegas Raiders | Tanner Muse | DB | Clemson |
| 3 | 101 | New England Patriots | Dalton Keene | TE | Virginia Tech |
| 3 | 102 | Pittsburge Steelers | Alex Highsmith | DE | Charlotte |
| 3 | 103 | Philadelphia Eagles | Davion Taylor | LB | Colorado |
| 3 | 104 | Los Angeles Rams | Terrell Burgess | DB | Utah |
| 3 | 105 | New Orleans Saints | Adam Trautman | TE | Dayton |
| 3 | 106 | Baltimore Ravens | Tyre Phillips | G | Mississippi State |
| Round | Pick | Team | Player | Position | College | |||
| 4 | 107 | Cincinnati Bengals | Akeem Davis-Gaither | LB | Appalachian State | |||
| 4 | 108 | Washington Football Team | Saahdiq Charles | T | Louisiana State | Redskins | ||
| 4 | 109 | Las Vegas Raiders | John Simpson | G | Clemson | Raiders | ||
| 4 | 110 | New York Giants | Darnay Holmes | DB | UCLA | Giants | ||
| 4 | 111 | Miami Dolphins | Solomon Kindley | G | Georgia | Dolphins | ||
| 4 | 112 | Los Angeles Chargers | Joshua Kelley | RB | UCLA | Chargers | ||
| 4 | 113 | Carolina Panthers | Troy Pride | DB | Notre Dame | Panthers | ||
| 4 | 114 | Arizona Cardinals | Leki Fotu | DT | Utah | Cardinals | ||
| 4 | 115 | Cleveland Browns | Harrison Bryant | TE | Florida Atlantic | Browns | ||
| 4 | 116 | Jacksonville Jaguars | Ben Bartch | T | St. John's (MN) | Jaguars | ||
| 4 | 117 | Minnesota Vikings | D.J. Wonnum | DE | South Carolina | Vikings | ||
| 4 | 118 | Denver Broncos | Albert Okwuegbunam | TE | Missouri | Broncos | ||
| 4 | 119 | Atlanta Falcons | Mykal Walker | LB | Fresno State | Falcons | ||
| 4 | 120 | New York Jets | Lamical Perine | RB | Florida | Jets | ||
| 4 | 121 | Detriot Lions | Logan Stenberg | G | Kentucky | Lions | ||
| 4 | 122 | Indianapolis Colts | Jacob Eason | QB | Washington | Colts | ||
| 4 | 123 | Dallas Cowboys | Reggie Robinson | DB | Tulsa | Cowboys | ||
| 4 | 124 | Pittsburge Steelers | Anthony McFarland Jr. | RB | Maryland | Steelers | ||
| 4 | 125 | New York Jets | James Morgan | QB | Florida International | Jets | ||
| 4 | 126 | Houston Texans | Charlie Heck | T | North Carolina | Texans | ||
| 4 | 127 | Philadelphia Eagles | K'Von Wallace | DB | Clemson | Eagles | ||
| 4 | 128 | Buffalo Bills | Gabriel Davis | WR | Central Florida | Bills | ||
| 4 | 129 | New York Jets | Cameron Clark | G | Charlotte | Jets | ||
| 4 | 130 | Minnesota Vikings | James Lynch | DE | Baylor | Vikings | ||
| 4 | 131 | Arizona Cardinals | Rashard Lawrence | DT | Louisiana State | Cardinals | ||
| 4 | 132 | Minnesota Vikings | Troy Dye | LB | Oregon | Vikings | ||
| 4 | 133 | Seattle Seahawks | Colby Parkinson | TE | Stanford | Seahawks | ||
| 4 | 134 | Atlanta Falcons | Jaylinn Hawkins | DB | California | Falcons | ||
| 4 | 135 | Pittsburge Steelers | Kevin Dotson | G | Louisiana-Lafayette | Steelers | ||
| 4 | 136 | Los Angeles Rams | Brycen Hopkins | TE | Purdue | Rams | ||
| 4 | 137 | Jacksonville Jaguars | Josiah Scott | DB | Michigan State | Jaguars | ||
| 4 | 138 | Kansas City Chiefs | L'Jarius Sneed | DB | Louisiana Tech | Chiefs | ||
| 4 | 139 | Las Vegas Raiders | Amik Robertson | DB | Louisiana Tech | Raiders | ||
| 4 | 140 | Jacksonville Jaguars | Shaquille Quarterman | LB | Miami (FL) | Jaguars | ||
| 4 | 141 | Houston Texans | John Reid | DB | Penn State | Texans | ||
| 4 | 142 | Washington Football Team | Antonio Gandy-Golden | WR | Liberty | Redskins | ||
| 4 | 143 | Baltimore Ravens | Ben Bredeson | G | Michigan | Ravens | ||
| 4 | 144 | Seattle Seahawks | DeeJay Dallas | RB | Miami (FL) | Seahawks | ||
| 4 | 145 | Philadelphia Eagles | Jack Driscoll | T | Auburn | Eagles | ||
| 4 | 146 | Dallas Cowboys | Tyler Biadasz | C | Wisconsin | Cowboys |
| Round | Pick | Team | Player | Position | College |
| 5 | 147 | Cincinnati Bengals | Khalid Kareem | DE | Notre Dame |
| 5 | 148 | Seattle Seahawks | Alton Robinson | DE | Syracuse |
| 5 | 149 | Indianapolis Colts | Danny Pinter | G | Ball State |
| 5 | 150 | New York Giants | Shane Lemieux | G | Oregon |
| 5 | 151 | Los Angeles Chargers | Joe Reed | WR | Virginia |
| 5 | 152 | Carolina Panthers | Kenny Robinson | DB | West Virginia |
| 5 | 153 | San Francisco 49ers | Colton McKivitz | T | West Virginia |
| 5 | 154 | Miami Dolphins | Jason Strowbridge | DE | North Carolina |
| 5 | 155 | Chicago Bears | Trevis Gipson | LB | Tulsa |
| 5 | 156 | Washington Football Team | Keith Ismael | C | San Diego State |
| 5 | 157 | Jacksonville Jaguars | Daniel Thomas | DB | Auburn |
| 5 | 158 | New York Jets | Bryce Hall | DB | Virginia |
| 5 | 159 | New England Patriots | Justin Rohrwasser | K | Marshall |
| 5 | 160 | Cleveland Browns | Nick Harris | C | Washington |
| 5 | 161 | Tampa Bay Buccaneers | Tyler Johnson | WR | Minnesota |
| 5 | 162 | Washington Football Team | Khaleke Hudson | LB | Michigan |
| 5 | 163 | Chicago Bears | Kindle Vildor | DB | Georgia Southern |
| 5 | 164 | Miami Dolphins | Curtis Weaver | DE | Boise State |
| 5 | 165 | Jacksonville Jaguars | Collin Johnson | WR | Texas |
| 5 | 166 | Detriot Lions | Quintez Cephus | WR | Wisconsin |
| 5 | 167 | Buffalo Bills | Jake Fromm | QB | Georgia |
| 5 | 168 | Philadelphia Eagles | John Hightower | WR | Boise State |
| 5 | 169 | Minnesota Vikings | Harrison Hand | DB | Temple |
| 5 | 170 | Baltimore Ravens | Broderick Washington | DT | Texas Tech |
| 5 | 171 | Houston Texans | Isaiah Coulter | WR | Rhode Island |
| 5 | 172 | Detriot Lions | Jason Huntley | RB | New Mexico State |
| 5 | 173 | Chicago Bears | Darnell Mooney | WR | Tulane |
| 5 | 174 | Tennessee Titans | Larrell Murchison | DT | North Carolina State |
| 5 | 175 | Green Bay Packers | Kamal Martin | LB | Minnesota |
| 5 | 176 | Minnesota Vikings | K.J. Osborn | WR | Miami (FL) |
| 5 | 177 | Kansas City Chiefs | Michael Danna | DE | Michigan |
| 5 | 178 | Denver Broncos | Justin Strnad | LB | Wake Forest |
| 5 | 179 | Dallas Cowboys | Bradlee Anae | DE | Utah |
| Round | Pick | Team | Player | Position | College |
| 6 | 180 | Cincinnati Bengals | Hakeem Adeniji | T | Kansas |
| 6 | 181 | Denver Broncos | Netane Muti | G | Fresno State |
| 6 | 182 | New England Patriots | Michael Onwenu | G | Michigan |
| 6 | 183 | New York Giants | Cam Brown | LB | Penn State |
| 6 | 184 | Carolina Panthers | Bravvion Roy | DT | Baylor |
| 6 | 185 | Miami Dolphins | Blake Ferguson | C | Louisiana State |
| 6 | 186 | Los Angeles Chargers | Alohi Gilman | DB | Notre Dame |
| 6 | 187 | Cleveland Browns | Donovan Peoples-Jones | WR | Michigan |
| 6 | 188 | Buffalo Bills | Tyler Bass | K | Georgia Southern |
| 6 | 189 | Jacksonville Jaguars | Jake Luton | QB | Oregon State |
| 6 | 190 | San Francisco 49ers | Charlie Woerner | TE | Georgia |
| 6 | 191 | New York Jets | Braden Mann | P | Texas A&M |
| 6 | 192 | Green Bay Packers | Jon Runyan | G | Michigan |
| 6 | 193 | Indianapolis Colts | Robert Windsor | Dt | Penn State |
| 6 | 194 | Tampa Bay Buccaneers | Khalil Davis | DT | Nebraska |
| 6 | 195 | New England Patriots | Justin Herron | T | Wake Forest |
| 6 | 196 | Philadelphia Eagles | Shaun Bradley | LB | Temple |
| 6 | 197 | Detriot Lions | John Penisini | DT | Utah |
| 6 | 198 | Pittsburge Steelers | Antoine Brooks | DB | Maryland |
| 6 | 199 | Los Angeles Rams | Jordan Fuller | DB | Ohio State |
| 6 | 200 | Philadelphia Eagles | Quez Watkins | WR | Southern Mississippi |
| 6 | 201 | Baltimore Ravens | James Proche | WR | Southern Methodist |
| 6 | 202 | Arizona Cardinals | Evan Weaver | LB | California |
| 6 | 203 | Minnesota Vikings | Blake Brandel | T | Oregon State |
| 6 | 204 | New England Patriots | Cassh Maluia | LB | Wyoming |
| 6 | 205 | Minnesota Vikings | Josh Metellus | DB | Michigan |
| 6 | 206 | Jacksonville Jaguars | Tyler Davis | TE | Georgia Tech |
| 6 | 207 | Buffalo Bills | Isaiah Hodgins | WR | Oregon State |
| 6 | 208 | Green Bay Packers | Jake Hanson | C | Oregon |
| 6 | 209 | Green Bay Packers | Simon Stepaniak | T | Indiana |
| 6 | 210 | Philadelphia Eagles | Prince Tega Wanogho | T | Auburn |
| 6 | 211 | Indianapolis Colts | Isaiah Rodgers | DB | Massachusetts |
| 6 | 212 | Indianapolis Colts | Dezmon Patmon | WR | Washington State |
| 6 | 213 | Indianapolis Colts | Jordan Glasgow | LB | Michigan |
| 6 | 214 | Seattle Seahawks | Freddie Swain | WR | Florida |
| Round | Pick | Team | Player | Position | College | |||
| 7 | 215 | Cincinnati Bengals | Markus Bailey | LB | Purdue | Bengals | ||
| 7 | 216 | Washington Football Team | Kamren Curl | DB | Arkansas | Redskins | ||
| 7 | 217 | San Francisco 49ers | Jauan Jennings | WR | Tennessee | 49ers | ||
| 7 | 218 | New York Giants | Carter Coughlin | LB | Minnesota | Giants | ||
| 7 | 219 | Baltimore Ravens | Geno Stone | DB | Iowa | Ravens | ||
| 7 | 220 | Los Angeles Chargers | K.J. Hill | WR | Ohio State | Chargers | ||
| 7 | 221 | Carolina Panthers | Stantley Thomas-Oliver | DB | Florida International | Panthers | ||
| 7 | 222 | Arizona Cardinals | Eno Benjamin | RB | Arizona State | Cardinals | ||
| 7 | 223 | Jacksonville Jaguars | Chris Claybrooks | DB | Memphis | Jaguars | ||
| 7 | 224 | Tennessee Titans | Cole McDonald | QB | Hawaii | Titans | ||
| 7 | 225 | Minnesota Vikings | Kenny Willekes | DE | Michigan State | Vikings | ||
| 7 | 226 | Chicago Bears | Arlington Hambright | T | Colorado | Bears | ||
| 7 | 227 | Chicago Bears | Lachavious Simmons | G | Tennessee State | Bears | ||
| 7 | 228 | Atlanta Falcons | Sterling Hofrichter | P | Syracuse | Falcons | ||
| 7 | 229 | Washington Football Team | James Smith-Williams | DE | North Carolina State | Redskins | ||
| 7 | 230 | New England Patriots | Dustin Woodard | C | Memphis | Patriots | ||
| 7 | 231 | Dallas Cowboys | Ben DiNucci | QB | James Madison | Cowboys | ||
| 7 | 232 | Pittsburge Steelers | Carlos Davis | DT | Nebraska | Steelers | ||
| 7 | 233 | Philadelphia Eagles | Casey Toohill | LB | Stanford | Eagles | ||
| 7 | 234 | Los Angeles Rams | Clay Johnston | LB | Baylor | Rams | ||
| 7 | 235 | Detriot Lions | Jashon Cornell | DE | Ohio State | Lions | ||
| 7 | 236 | Green Bay Packers | Vernon Scott | DB | Texas Christian | Packers | ||
| 7 | 237 | Kansas City Chiefs | Thakarius Keyes | DB | Tulane | Chiefs | ||
| 7 | 238 | New York Giants | T.J. Brunson | LB | South Carolina | Giants | ||
| 7 | 239 | Buffalo Bills | Dane Jackson | DB | Pittsburgh | Bills | ||
| 7 | 240 | New Orleans Saints | Tommy Stevens | QB | Mississippi State | Saints | ||
| 7 | 241 | Tampa Bay Buccaneers | Chapelle Russell | LB | Temple | Buccaneers | ||
| 7 | 242 | Green Bay Packers | Jonathan Garvin | DE | Miami (FL) | Packers | ||
| 7 | 243 | Tennessee Titans | Chris Jackson | DB | Marshall | Titans | ||
| 7 | 244 | Minnesota Vikings | Nate Stanley | QB | Iowa | Vikings | ||
| 7 | 245 | Tampa Bay Buccaneers | Raymond Calais | RB | Louisiana-Lafayette | Buccaneers | ||
| 7 | 246 | Miami Dolphins | Malcolm Perry | WR | Navy | Dolphins | ||
| 7 | 247 | New York Giants | Chris Williamson | DB | Minnesota | Giants | ||
| 7 | 248 | Los Angeles Rams | Sam Sloman | K | Miami (OH) | Rams | ||
| 7 | 249 | Minnesota Vikings | Brian Cole | DB | Mississippi State | Vikings | ||
| 7 | 250 | Los Angeles Rams | Tremayne Anchrum | G | Clemson | Rams | ||
| 7 | 251 | Seattle Seahawks | Stephen Sullivan | TE | Louisiana State | Seahawks | ||
| 7 | 252 | Denver Broncos | Tyrie Cleveland | WR | Florida | Broncos | ||
| 7 | 253 | Minnesota Vikings | Kyle Hinton | G | Washburn | Vikings | ||
| 7 | 254 | Denver Broncos | Derrek Tuszka | LB | North Dakota State | Broncos | ||
| 7 | 255 | New York Giants | Tae Crowder | LB | Georgia | Giants |